TRP Channel
TRP channels (Transient receptor potential channels) are a group of ion channels located mostly on the plasma membrane of numerous animal cell types. There are about 28 TRP channels that share some structural similarity to each other. These are grouped into two broad groups: Group 1 includes TRPC,TRPV,TRPM,TRPN, and TRPA. In group 2, there are TRPP ,and TRPML. Many of these channels mediate a variety of sensations like the sensations of pain, hotness, warmth or coldness, different kinds of tastes, pressure, and vision. TRPs have been seen to have complex multidimensional roles in sensory signaling. Many TRPs function as intracellular calcium release channels.
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SN 2是选择性TRPML3通道激动剂。
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SKF 96365 hydrochloride是TRPC 通道阻断剂（SKF 96365 hydrochloride could inhibit store-operated Ca2+ entry）。
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SB 366791是活性选择性竞争性 TRPV1 拮抗剂。
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SB 452533是活性的 TRPV1 受体拮抗剂。
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RQ 00203078是活性选择性TRPM8的拮抗剂， 口服有效。
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